From October 16 to 20, 2023, the PRION2023 conference was held in the Portuguese city of Faro, where scientists from various countries once again gathered to discuss prions and prion diseases. The event featured numerous lectures from invited guests and selected presentations, complemented by the traditional poster session, where participants could also review the research findings of our laboratory. The abstract of the contribution "Discordant RT-QuIC results in siblings with genetic Creutzfeldt-Jakob disease linked to a rare five octapeptide repeats insertion in PRNP gene" can be viewed here.