The world's largest prion conference PRION2018 took place on 22–25 May in the historic Galician town of Santiago de Compostela. Again, representatives of our laboratory were not absent and contributed the rich program with poster presentations on topics "Searching for disappearing prions: the mechanism behind photodynamic inactivation by phthalocyanines", "Differences in the efficiency of prion infection of CAD5 cells by distinct fractions of extracellular vesicles" and "Cellular prion protein expression, processing and localization is affected during differentiation of mouse neuronal cell line CAD5".